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Dislipidemia

L. A. PRAMONO

Fakultas Kedokteran Universitas Indonesia

Definisi

Dislipidemia adalah kelainan metabolisme lipid yang ditandai dengan pe­ning­katan maupun penurunan fraksi lipid dalam plasma. Dislipidemia mengacu pada kondisi di mana terjadi abnormalitas profil lipid dalam plasma.

Beberapa kelainan fraksi lipid yang utama adalah kenaikan kadar kolesterol total, kolesterol LDL, trigliserida (TG), serta penurunan kolesterol HDL. Berbagai perubahan profil lipid tersebut saling terkait satu dengan lain sehingga tidak dapat dibicarakan sendiri-sendiri.

Dislipidemia merupakan salah satu faktor risiko utama aterosklerosis dan penyakit jantun­g koroner. Dislipidemia adalah salah satu komponen dalam trias sindrom meta­boli­k selain diabetes dan hipertensi.

Aspek Biokimia Lipid

Lipid merupakan substansi yang bersifat hidrofobik. Artinya, dalam keadaan normal tanpa molekul pengikat, lipid tidak dapat larut dalam plasma darah. Agar lipid dapat larut dalam darah, lipid berikatan dengan apolipoprotein membentuk lipoprotein. Pemahaman tentang apolipoprotein dan lipoprotein penting karena berperan dalam patofisiologi tipe-tipe dislipidemia tertentu.

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